Hi all,
I am not sure if BindCraft is able to generate binders against a protein with a ligand, taking into account the ligand during the inference. Is that so? If it is not, are you planning on adding this for BindCraft2. I think that this will be a good add-on as many proteins rely on ligands to perform their catalytic activites, changing their conformation even after ligand binding. So maybe designing binders against the apo-enzyme will not serve if this is not the real situation in the cell.
Looking forward to your answers, great job indeed, I try to follow you in every binder design competition.
Hi all,
I am not sure if BindCraft is able to generate binders against a protein with a ligand, taking into account the ligand during the inference. Is that so? If it is not, are you planning on adding this for BindCraft2. I think that this will be a good add-on as many proteins rely on ligands to perform their catalytic activites, changing their conformation even after ligand binding. So maybe designing binders against the apo-enzyme will not serve if this is not the real situation in the cell.
Looking forward to your answers, great job indeed, I try to follow you in every binder design competition.