diff --git a/CHANGELOG.md b/CHANGELOG.md
index d45c7d4..46b6306 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,7 @@
 
 - Header view: new view to inspect ELF and PE executables.
 - Added a command to change the view (same as pressing `Tab`). Example: `:set view hex` (possible values are `text`, `hex`, and `header`). It can be used in `~/.dz6init` to set the default view when dz6 is loaded.
+- Added support for comments / lines starting with `#` in `~/.dz6init`.
 
 ## Breaking changes:
 - `Tab` cycles through available views now (`Enter` no longer does that).
diff --git a/README.md b/README.md
index 18102d6..05954b9 100644
--- a/README.md
+++ b/README.md
@@ -120,7 +120,7 @@ Once you load a file in **dz6**, you can use the commands below.
 | `wq` or `x`      | Write changes to file and quit                                   |                           |                                                                                                   |
 | `q`              | Quit without saving changes                                      |                           | In replace mode, `T` (truncate) is an exception because it modifies the file immediately.         |
 
-If you need permanent settings, create a `$HOME/.dz6init` file containing any of the commands above, one per line. dz6 will load that at startup.
+> If you need permanent settings, create a `$HOME/.dz6init` file containing any of the commands above, one per line. dz6 will load that at startup. Lines starting with `#` are ignored.
 
 ### Hex view
 
diff --git a/src/initfile.rs b/src/initfile.rs
index bfe59a8..94673d5 100644
--- a/src/initfile.rs
+++ b/src/initfile.rs
@@ -13,7 +13,11 @@ impl App {
             let path = home.join(".dz6init");
             let data = fs::read_to_string(path)?;
 
-            for cmdline in data.lines() {
+            for cmdline in data
+                .lines()
+                .map(str::trim)
+                .filter(|line| !line.starts_with('#'))
+            {
                 parse_command(self, cmdline);
             }
         }