diff --git a/doc/examples/scripts/structure/modeling/docking.py b/doc/examples/scripts/structure/modeling/docking.py
index 9fb63f201..41661c786 100644
--- a/doc/examples/scripts/structure/modeling/docking.py
+++ b/doc/examples/scripts/structure/modeling/docking.py
@@ -65,7 +65,8 @@
 # of the original ligand position
 app = autodock.VinaApp(ligand, receptor, ref_ligand_center, [20, 20, 20])
 # For reproducibility
-app.set_seed(0)
+# (Vina interprets seed 0 as a request for a random seed, so use a non-zero one)
+app.set_seed(42)
 app.set_cpu(1)
 # This is the maximum number:
 # Vina may find less interesting binding modes
diff --git a/tests/application/test_autodock.py b/tests/application/test_autodock.py
index fb4638b54..0d3531de0 100644
--- a/tests/application/test_autodock.py
+++ b/tests/application/test_autodock.py
@@ -49,7 +49,9 @@ def test_docking(flexible):
         [20, 20, 20],
         flexible=flexible_mask,
     )
-    app.set_seed(0)
+    # A non-zero seed is required: Vina interprets seed 0 as a request for
+    # a random seed, which would make this test non-deterministic
+    app.set_seed(42)
     # Single-threaded execution is required for fully reproducible
     # results — even with a fixed seed, parallel Vina is not deterministic
     app.set_cpu(1)