biolink-model.proto

 syntax="proto3";
 package
// metamodel_version: 1.7.0
// version: 3.0.3
// An activity is something that occurs over a period of time and acts upon or with entities; it may include consuming, processing, transforming, modifying, relocating, using, or generating entities.
message Activity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// person, group, organization or project that provides a piece of information (i.e. a knowledge association)
message Agent
 {
  iriType iri = 0
  string type = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  uriorcurie affiliation = 0
  string address = 0
  string id = 0
  labelType name = 0
 }
// A subcellular location, cell type or gross anatomical part
message AnatomicalEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship.
message AnatomicalEntityToAnatomicalEntityOntogenicAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  anatomicalEntity subject = 0
  anatomicalEntity object = 0
  predicateType predicate = 0
 }
// A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms
message AnatomicalEntityToAnatomicalEntityPartOfAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  anatomicalEntity subject = 0
  anatomicalEntity object = 0
  predicateType predicate = 0
 }
message Article
 {
  iriType iri = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 repeated  string authors = 0
 repeated  string pages = 0
  string summary = 0
 repeated  string keywords = 0
 repeated  uriorcurie meshTerms = 0
 repeated  uriorcurie xref = 0
  string id = 0
  labelType name = 0
  string type = 0
  uriorcurie publishedIn = 0
  string isoAbbreviation = 0
  string volume = 0
  string issue = 0
 }
// A typed association between two entities, supported by evidence
message Association
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
 }
// A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material.
message Attribute
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
message Behavior
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  biologicalProcessOrActivity hasInput = 0
 repeated  biologicalProcessOrActivity hasOutput = 0
 repeated  physicalEntity enabledBy = 0
 }
// An association between an mixture behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior.
message BehaviorToBehavioralFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  behavior subject = 0
  behavioralFeature object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
// A behavioral exposure is a factor relating to behavior impacting an individual.
message BehavioralExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
// A phenotypic feature which is behavioral in nature.
message BehavioralFeature
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
// One or more causally connected executions of molecular functions
message BiologicalProcess
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  biologicalProcessOrActivity hasInput = 0
 repeated  biologicalProcessOrActivity hasOutput = 0
 repeated  physicalEntity enabledBy = 0
 }
// Either an individual molecular activity, or a collection of causally connected molecular activities in a biological system.
message BiologicalProcessOrActivity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  biologicalProcessOrActivity hasInput = 0
 repeated  biologicalProcessOrActivity hasOutput = 0
 repeated  physicalEntity enabledBy = 0
 }
message BiologicalSex
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses).
message BioticExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
// This class may rarely be instantiated except if use cases of a given knowledge graph support its utility.
message Book
 {
  iriType iri = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 repeated  string authors = 0
 repeated  string pages = 0
  string summary = 0
 repeated  string keywords = 0
 repeated  uriorcurie meshTerms = 0
 repeated  uriorcurie xref = 0
  labelType name = 0
  string id = 0
  string type = 0
 }
message BookChapter
 {
  iriType iri = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 repeated  string authors = 0
 repeated  string pages = 0
  string summary = 0
 repeated  string keywords = 0
 repeated  uriorcurie meshTerms = 0
 repeated  uriorcurie xref = 0
  string id = 0
  labelType name = 0
  string type = 0
  uriorcurie publishedIn = 0
  string volume = 0
  string chapter = 0
 }
// An individual (human) organism that has a patient role in some clinical context.
message Case
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype.
message CaseToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
message Cell
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
message CellLine
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
message CellLineAsAModelOfDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  cellLine subject = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
 }
// An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype.
message CellLineToDiseaseOrPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  diseaseOrPhenotypicFeature subject = 0
 }
// A location in or around a cell
message CellularComponent
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
message CellularOrganism
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// Describes an effect that a chemical has on a gene or gene product (e.g. an impact of on its abundance, activity, localization, processing, expression, etc.)
message ChemicalAffectsGeneAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  chemicalOrGeneOrGeneProductFormEnum subjectFormOrVariantQualifier = 0
  geneOrGeneProductOrChemicalPartQualifierEnum subjectPartQualifier = 0
  chemicalEntityDerivativeEnum subjectDerivativeQualifier = 0
  geneOrGeneProductOrChemicalEntityAspectEnum subjectAspectQualifier = 0
  anatomicalEntity subjectContextQualifier = 0
  directionQualifierEnum subjectDirectionQualifier = 0
  chemicalOrGeneOrGeneProductFormEnum objectFormOrVariantQualifier = 0
  geneOrGeneProductOrChemicalPartQualifierEnum objectPartQualifier = 0
  geneOrGeneProductOrChemicalEntityAspectEnum objectAspectQualifier = 0
  anatomicalEntity objectContextQualifier = 0
  causalMechanismQualifierEnum causalMechanismQualifier = 0
  anatomicalEntity anatomicalContextQualifier = 0
  string qualifiedPredicate = 0
  chemicalEntity subject = 0
  predicateType predicate = 0
  geneOrGeneProduct object = 0
  directionQualifierEnum objectDirectionQualifier = 0
  organismTaxon speciesContextQualifier = 0
 }
// A chemical entity is a physical entity that pertains to chemistry or biochemistry.
message ChemicalEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
message ChemicalEntityAssessesNamedThingAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  chemicalEntity subject = 0
  namedThing object = 0
  predicateType predicate = 0
 }
// A regulatory relationship between two genes
message ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  directionQualifierEnum objectDirectionQualifier = 0
  predicateType predicate = 0
  chemicalEntityOrGeneOrGeneProduct subject = 0
  geneOrGeneProduct object = 0
 }
// A chemical exposure is an intake of a particular chemical entity.
message ChemicalExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 repeated  quantityValue hasQuantitativeValue = 0
  timeType timepoint = 0
 }
// describes a physical interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)
message ChemicalGeneInteractionAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  chemicalOrGeneOrGeneProductFormEnum subjectFormOrVariantQualifier = 0
  geneOrGeneProductOrChemicalPartQualifierEnum subjectPartQualifier = 0
  chemicalEntityDerivativeEnum subjectDerivativeQualifier = 0
  anatomicalEntity subjectContextQualifier = 0
  chemicalOrGeneOrGeneProductFormEnum objectFormOrVariantQualifier = 0
  geneOrGeneProductOrChemicalPartQualifierEnum objectPartQualifier = 0
  anatomicalEntity objectContextQualifier = 0
  anatomicalEntity anatomicalContextQualifier = 0
  chemicalEntity subject = 0
  geneOrGeneProduct object = 0
  predicateType predicate = 0
 }
// A chemical mixture is a chemical entity composed of two or more molecular entities.
message ChemicalMixture
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  chemicalMixture isSupplement = 0
  string highestFDAApprovalStatus = 0
  string drugRegulatoryStatusWorldWide = 0
 repeated  drugDeliveryEnum routesOfDelivery = 0
 }
// This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disesae or phenotypic feature is a secondary, typically (but not always) undesirable effect.
message ChemicalOrDrugOrTreatmentSideEffectDiseaseOrPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  fDAIDAAdverseEventEnum fDAAdverseEventLevel = 0
  predicateType predicate = 0
 }
// This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disesae or phenotypic feature is a secondary undesirable effect.
message ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  fDAIDAAdverseEventEnum fDAAdverseEventLevel = 0
  predicateType predicate = 0
 }
message ChemicalRole
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another.
message ChemicalToChemicalAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  chemicalEntity object = 0
 }
// A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
//   IF
//   R has-input C1 AND
//   R has-output C2 AND
//   R enabled-by P AND
//   R type Reaction
//   THEN
//   C1 derives-into C2 <<catalyst qualifier P>>
message ChemicalToChemicalDerivationAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
 repeated  macromolecularMachineMixin catalystQualifier = 0
  chemicalEntity subject = 0
  chemicalEntity object = 0
  predicateType predicate = 0
 }
// An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype.
message ChemicalToDiseaseOrPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  diseaseOrPhenotypicFeature object = 0
 }
// An interaction between a chemical entity and a gene or gene product.
message ChemicalToGeneAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct object = 0
 }
// An interaction between a chemical entity and a biological process or pathway.
message ChemicalToPathwayAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  chemicalEntity subject = 0
  pathway object = 0
 }
// A result of a chi squared analysis.
message ChiSquaredAnalysisResult
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// Attributes relating to a clinical manifestation
message ClinicalAttribute
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual
message ClinicalCourse
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities
message ClinicalEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations.
message ClinicalFinding
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  clinicalAttribute hasAttribute = 0
 }
message ClinicalIntervention
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot.
message ClinicalMeasurement
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  ontologyClass hasAttributeType = 0
 }
// Used to characterize and specify the phenotypic abnormalities defined in the phenotypic abnormality sub-ontology, with respect to severity, laterality, and other aspects
message ClinicalModifier
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
message ClinicalTrial
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
message CodingSequence
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 }
// A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time.
message Cohort
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// A complex chemical exposure is an intake of a chemical mixture (e.g. gasoline), other than a drug.
message ComplexChemicalExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A complex molecular mixture is a chemical mixture composed of two or more molecular entities with unknown concentration and stoichiometry.
message ComplexMolecularMixture
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  chemicalMixture isSupplement = 0
  string highestFDAApprovalStatus = 0
  string drugRegulatoryStatusWorldWide = 0
 repeated  drugDeliveryEnum routesOfDelivery = 0
 }
// A result of a concept count analysis.
message ConceptCountAnalysisResult
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// Level of confidence in a statement
message ConfidenceLevel
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// Any association between an entity (such as a publication) and various agents that contribute to its realisation
message ContributorAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  informationContentEntity subject = 0
  predicateType predicate = 0
  agent object = 0
 repeated  ontologyClass qualifiers = 0
 }
// an item that refers to a collection of data from a data source.
message Dataset
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// an item that holds distribution level information about a dataset.
message DatasetDistribution
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
  string distributionDownloadUrl = 0
 }
// an item that holds summary level information about a dataset.
message DatasetSummary
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
  string sourceWebPage = 0
  string sourceLogo = 0
 }
// an item that holds version level information about a dataset.
message DatasetVersion
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
  dataset hasDataset = 0
  string ingestDate = 0
  datasetDistribution hasDistribution = 0
 }
// A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment
message Device
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// A disorder of structure or function, especially one that produces specific  signs, phenotypes or symptoms or that affects a specific location and is not simply a  direct result of physical injury.  A disposition to undergo pathological processes that exists in an  organism because of one or more disorders in that organism.
message Disease
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
// Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate.  Please see definitions of phenotypic feature and disease in this model for their independent descriptions.  This class is helpful to enforce domains and ranges   that may involve either a disease or a phenotypic feature.
message DiseaseOrPhenotypicFeature
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
// A disease or phenotypic feature state, when viewed as an exposure, represents an precondition, leading to or influencing an outcome, e.g. HIV predisposing an individual to infections; a relative deficiency of skin pigmentation predisposing an individual to skin cancer.
message DiseaseOrPhenotypicFeatureExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
// An association between either a disease or a phenotypic feature and its mode of (genetic) inheritance.
message DiseaseOrPhenotypicFeatureToGeneticInheritanceAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  geneticInheritance object = 0
 }
// An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site.
message DiseaseOrPhenotypicFeatureToLocationAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  anatomicalEntity object = 0
 }
// An association between an exposure event and a disease.
message DiseaseToExposureEventAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
 }
// An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way.
message DiseaseToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  disease subject = 0
  phenotypicFeature object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
// A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease
message Drug
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  chemicalMixture isSupplement = 0
  string highestFDAApprovalStatus = 0
  string drugRegulatoryStatusWorldWide = 0
 repeated  drugDeliveryEnum routesOfDelivery = 0
 }
// A drug exposure is an intake of a particular drug.
message DrugExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 repeated  quantityValue hasQuantitativeValue = 0
  timeType timepoint = 0
 }
// An interaction between a drug and a gene or gene product.
message DrugToGeneAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct object = 0
 }
// drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome.
message DrugToGeneInteractionExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 repeated  quantityValue hasQuantitativeValue = 0
  timeType timepoint = 0
 repeated  gene hasGeneOrGeneProduct = 0
 }
message DruggableGeneToDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  disease object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  geneOrGeneProduct subject = 0
  predicateType predicate = 0
 repeated  druggableGeneCategoryEnum hasEvidence = 0
 }
message EntityToDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  fDAApprovalStatusEnum fDAApprovalStatus = 0
 }
message EntityToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  fDAApprovalStatusEnum fDAApprovalStatus = 0
 }
// A environmental exposure is a factor relating to abiotic processes in the environment including sunlight (UV-B), atmospheric (heat, cold, general pollution) and water-born contaminants.
message EnvironmentalExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
message EnvironmentalFeature
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
message EnvironmentalFoodContaminant
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
message EnvironmentalProcess
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// Something that happens at a given place and time.
message Event
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// Class of evidence that supports an association
message EvidenceType
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing.
message Exon
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 }
// A transcript is formed from multiple exons
message ExonToTranscriptRelationship
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  exon subject = 0
  transcript object = 0
 }
// An association between an exposure event and an outcome.
message ExposureEventToOutcomeAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  populationOfIndividualOrganisms hasPopulationContext = 0
  timeType hasTemporalContext = 0
 }
// Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype.
message ExposureEventToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  exposureEvent subject = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
// A substance consumed by a living organism as a source of nutrition
message Food
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  chemicalMixture isSupplement = 0
  string highestFDAApprovalStatus = 0
  string drugRegulatoryStatusWorldWide = 0
 repeated  drugDeliveryEnum routesOfDelivery = 0
 }
message FoodAdditive
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
// An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed.
message FunctionalAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  macromolecularMachineMixin subject = 0
  geneOntologyClass object = 0
 }
// A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene locus may include regulatory regions, transcribed regions and/or other functional sequence regions.
message Gene
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
  string symbol = 0
 repeated  labelType synonym = 0
 repeated  uriorcurie xref = 0
  biologicalSequence hasBiologicalSequence = 0
 }
message GeneAsAModelOfDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  disease object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  geneOrGeneProduct subject = 0
 }
// any grouping of multiple genes or gene products related by common descent
message GeneFamily
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  gene hasGeneOrGeneProduct = 0
 }
message GeneHasVariantThatContributesToDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  disease object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  sequenceVariant sequenceVariantQualifier = 0
  geneOrGeneProduct subject = 0
 }
// A regulatory relationship between two genes
message GeneRegulatoryRelationship
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  geneOrGeneProduct subject = 0
  geneOrGeneProduct object = 0
 }
message GeneToDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct subject = 0
  disease object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
 }
// An association between a gene and a gene expression site, possibly qualified by stage/timing info.
message GeneToExpressionSiteAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  lifeStage stageQualifier = 0
  ontologyClass quantifierQualifier = 0
  geneOrGeneProduct subject = 0
  anatomicalEntity object = 0
  predicateType predicate = 0
 }
// Indicates that two genes are co-expressed, generally under the same conditions.
message GeneToGeneCoexpressionAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct subject = 0
  geneOrGeneProduct object = 0
  predicateType predicate = 0
  ontologyClass quantifierQualifier = 0
  anatomicalEntity expressionSite = 0
  lifeStage stageQualifier = 0
  diseaseOrPhenotypicFeature phenotypicState = 0
 }
// A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)
message GeneToGeneHomologyAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct subject = 0
  predicateType predicate = 0
  geneOrGeneProduct object = 0
 }
// A gene is transcribed and potentially translated to a gene product
message GeneToGeneProductRelationship
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  gene subject = 0
  geneProductMixin object = 0
  predicateType predicate = 0
 }
message GeneToGoTermAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  gene subject = 0
  geneOntologyClass object = 0
 }
// An interaction between a gene or gene product and a biological process or pathway.
message GeneToPathwayAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct subject = 0
  pathway object = 0
 }
message GeneToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct subject = 0
  phenotypicFeature object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
// The pattern or 'mode' in which a particular genetic trait or disorder is passed from one generation to the next, e.g. autosomal dominant, autosomal recessive, etc.
message GeneticInheritance
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
// A genome is the sum of genetic material within a cell or virion.
message Genome
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
  biologicalSequence hasBiologicalSequence = 0
 }
// A genomic background exposure is where an individual's specific genomic background of genes, sequence variants or other pre-existing genomic conditions constitute a kind of 'exposure' to the organism, leading to or influencing an outcome.
message GenomicBackgroundExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 repeated  gene hasGeneOrGeneProduct = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 }
// A relationship between a sequence feature and a nucleic acid entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig.
message GenomicSequenceLocalization
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  integer startInterbaseCoordinate = 0
  integer endInterbaseCoordinate = 0
  strandEnum genomeBuild = 0
  strandEnum strand = 0
  phaseEnum phase = 0
  nucleicAcidEntity subject = 0
  nucleicAcidEntity object = 0
  predicateType predicate = 0
 }
// An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some established background
message Genotype
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
  zygosity hasZygosity = 0
  biologicalSequence hasBiologicalSequence = 0
 }
message GenotypeAsAModelOfDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  namedThing object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  genotype subject = 0
 }
message GenotypeToDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
 }
// Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality
message GenotypeToGeneAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  genotype subject = 0
  gene object = 0
 }
// Any association between one genotype and a genotypic entity that is a sub-component of it
message GenotypeToGenotypePartAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  genotype subject = 0
  genotype object = 0
 }
// Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment
message GenotypeToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  genotype subject = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
// Any association between a genotype and a sequence variant.
message GenotypeToVariantAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  genotype subject = 0
  sequenceVariant object = 0
 }
// An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes.
message GenotypicSex
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A geographic exposure is a factor relating to geographic proximity to some impactful entity.
message GeographicExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
// a location that can be described in lat/long coordinates
message GeographicLocation
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  float latitude = 0
  float longitude = 0
 }
// a location that can be described in lat/long coordinates, for a particular time
message GeographicLocationAtTime
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  float latitude = 0
  float longitude = 0
  timeType timepoint = 0
 }
message GrossAnatomicalStructure
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// A set of zero or more Alleles on a single instance of a Sequence[VMC]
message Haplotype
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
  biologicalSequence hasBiologicalSequence = 0
 }
message Hospitalization
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// An instance of an organism. For example, Richard Nixon, Charles Darwin, my pet cat. Example ID: ORCID:0000-0002-5355-2576
message IndividualOrganism
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// association between a named thing and a information content entity where the specific context of the relationship between that named thing and the publication is unknown. For example, model organisms databases often capture the knowledge that a gene is found in a journal article, but not specifically the context in which that gene was documented in the article. In these cases, this association with the accompanying predicate 'mentions' could be used. Conversely, for more specific associations (like 'gene to disease association', the publication should be captured as an edge property).
message InformationContentEntityToNamedThingAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  namedThing subject = 0
  namedThing object = 0
  predicateType predicate = 0
 }
// A database or knowledgebase and its supporting ecosystem of interfaces  and services that deliver content to consumers (e.g. web portals, APIs,  query endpoints, streaming services, data downloads, etc.). A single Information Resource by this definition may span many different datasets or databases, and include many access endpoints and user interfaces. Information Resources include project-specific resources such as a Translator Knowledge Provider, and community knowledgebases like ChemBL, OMIM, or DGIdb.
message InformationResource
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// The name of this attribute and its inheritance from organism attribute, indeed, its designation as an attribute is problematic. First, the isolated word 'inheritance' is too ambiguous (especially when embedded inside an ontology with inheritance!). 'Genetic inheritance' would be more precise. Second, in terms of the scientific usage here, genetic inheritance would not be a direct property at the topmost organism level, but rather (as hinted in the definition) is more a commentary on the nature of phenotype (including  genetic disease as a characteristic set of associated phenotypes) against the (hidden) context of (meiotic/somatic/mitochondrial) DNA segregation and expression.  Third, placing  the term in the attribute, rather than named thing category concept hierarchy, is perhaps less flexible in terms of its usage as a first class concept for semantic queries. Thus, we deprecate this term, moving it to the 'new' category of 'genetic inheritance',  as a child of 'biological entity' (to emphasize its biological conceptual nature).
message Inheritance
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A stage of development or growth of an organism, including post-natal adult stages
message LifeStage
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it.
message MacromolecularMachineToBiologicalProcessAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  macromolecularMachineMixin subject = 0
  biologicalProcess object = 0
 }
// A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component.
message MacromolecularMachineToCellularComponentAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  macromolecularMachineMixin subject = 0
  cellularComponent object = 0
 }
// A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution.
message MacromolecularMachineToMolecularActivityAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  macromolecularMachineMixin subject = 0
  molecularActivity object = 0
 }
message Macronutrient
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
// A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]
message MaterialSample
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// An association between a material sample and the material entity from which it is derived.
message MaterialSampleDerivationAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  materialSample subject = 0
  namedThing object = 0
  predicateType predicate = 0
 }
// An association between a material sample and a disease or phenotype.
message MaterialSampleToDiseaseOrPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
 }
message Micronutrient
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
message MicroRNA
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// An execution of a molecular function carried out by a gene product or macromolecular complex.
message MolecularActivity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  molecularEntity hasInput = 0
 repeated  molecularEntity hasOutput = 0
 repeated  macromolecularMachineMixin enabledBy = 0
 }
// Added in response to capturing relationship between microbiome activities as measured via measurements of blood analytes as collected via blood and stool samples
message MolecularActivityToChemicalEntityAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  molecularActivity subject = 0
  chemicalEntity object = 0
 }
// Added in response to capturing relationship between microbiome activities as measured via measurements of blood analytes as collected via blood and stool samples
message MolecularActivityToMolecularActivityAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  molecularActivity subject = 0
  molecularActivity object = 0
 }
// Association that holds the relationship between a reaction and the pathway it participates in.
message MolecularActivityToPathwayAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  molecularActivity subject = 0
  pathway object = 0
  predicateType predicate = 0
 }
// A molecular entity is a chemical entity composed of individual or covalently bonded atoms.
message MolecularEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
 }
// A molecular mixture is a chemical mixture composed of two or more molecular entities with known concentration and stoichiometry.
message MolecularMixture
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  chemicalMixture isSupplement = 0
  string highestFDAApprovalStatus = 0
  string drugRegulatoryStatusWorldWide = 0
 repeated  drugDeliveryEnum routesOfDelivery = 0
 }
// a databased entity or concept/class
message NamedThing
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
message NamedThingAssociatedWithLikelihoodOfNamedThingAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  string subjectAspectQualifier = 0
  ontologyClass subjectContextQualifier = 0
  string objectAspectQualifier = 0
  ontologyClass objectContextQualifier = 0
 }
message NoncodingRNAProduct
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// A nucleic acid entity is a molecular entity characterized by availability in gene databases of nucleotide-based sequence representations of its precise sequence; for convenience of representation, partial sequences of various kinds are included.
message NucleicAcidEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 }
// A linear nucleotide sequence pattern that is widespread and has, or is conjectured to have, a biological significance. e.g. the TATA box promoter motif, transcription factor binding consensus sequences.
message NucleicAcidSequenceMotif
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
message Nutrient
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
// A result of a observed expected frequency analysis.
message ObservedExpectedFrequencyAnalysisResult
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// The age group in which (disease) symptom manifestations appear
message Onset
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// describes a characteristic of an organismal entity.
message OrganismAttribute
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A classification of a set of organisms. Example instances: NCBITaxon:9606 (Homo sapiens), NCBITaxon:2 (Bacteria). Can also be used to represent strains or subspecies.
message OrganismTaxon
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  taxonomicRank hasTaxonomicRank = 0
 }
// An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens
message OrganismTaxonToOrganismTaxonInteraction
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  string associatedEnvironmentalContext = 0
  organismTaxon subject = 0
  organismTaxon object = 0
  predicateType predicate = 0
 }
// A child-parent relationship between two taxa. For example: Homo sapiens subclass_of Homo
message OrganismTaxonToOrganismTaxonSpecialization
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  organismTaxon subject = 0
  organismTaxon object = 0
  predicateType predicate = 0
 }
message OrganismToOrganismAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  individualOrganism subject = 0
  individualOrganism object = 0
 }
message OrganismalEntityAsAModelOfDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  organismalEntity subject = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
 }
// An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)
message PairwiseGeneToGeneInteraction
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  geneOrGeneProduct subject = 0
  geneOrGeneProduct object = 0
  predicateType predicate = 0
 }
// An interaction at the molecular level between two physical entities
message PairwiseMolecularInteraction
 {
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  ontologyClass interactingMoleculesCategory = 0
  molecularEntity subject = 0
  string id = 0
  predicateType predicate = 0
  molecularEntity object = 0
 }
// An abnormal anatomical structure, when viewed as an exposure, representing an precondition, leading to or influencing an outcome, e.g. thrombosis leading to an ischemic disease outcome.
message PathologicalAnatomicalExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
// An anatomical structure with the potential of have an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level.
message PathologicalAnatomicalStructure
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level.
message PathologicalProcess
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  biologicalProcessOrActivity hasInput = 0
 repeated  biologicalProcessOrActivity hasOutput = 0
 repeated  physicalEntity enabledBy = 0
 }
// A pathological process, when viewed as an exposure, representing a precondition, leading to or influencing an outcome, e.g. autoimmunity leading to disease.
message PathologicalProcessExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
  timeType timepoint = 0
 }
message Pathway
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  biologicalProcessOrActivity hasInput = 0
 repeated  biologicalProcessOrActivity hasOutput = 0
 repeated  physicalEntity enabledBy = 0
 }
// a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question
message Phenomenon
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// A combination of entity and quality that makes up a phenotyping statement. An observable characteristic of an  individual resulting from the interaction of its genotype with its molecular and physical environment.
message PhenotypicFeature
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
// A property of a phenotype
message PhenotypicQuality
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present.
message PhenotypicSex
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// An entity that has material reality (a.k.a. physical essence).
message PhysicalEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
message PhysiologicalProcess
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  biologicalProcessOrActivity hasInput = 0
 repeated  biologicalProcessOrActivity hasOutput = 0
 repeated  physicalEntity enabledBy = 0
 }
// Any entity or process that exists at the level of the whole planet
message PlanetaryEntity
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// A polypeptide is a molecular entity characterized by availability in protein databases of amino-acid-based sequence representations of its precise primary structure; for convenience of representation, partial sequences of various kinds are included, even if they do not represent a physical molecule.
message Polypeptide
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 }
// A collection of individuals from the same taxonomic class distinguished by one or more characteristics.  Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes.
message PopulationOfIndividualOrganisms
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
// An association between a two populations
message PopulationToPopulationAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  populationOfIndividualOrganisms subject = 0
  populationOfIndividualOrganisms object = 0
  predicateType predicate = 0
 }
// A series of actions conducted in a certain order or manner
message Procedure
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 }
// A chemical entity (often a mixture) processed for consumption for nutritional, medical or technical use. Is a material entity that is created or changed during material processing.
message ProcessedMaterial
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  chemicalMixture isSupplement = 0
  string highestFDAApprovalStatus = 0
  string drugRegulatoryStatusWorldWide = 0
 repeated  drugDeliveryEnum routesOfDelivery = 0
 }
// A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA
message Protein
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// A conserved part of protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Protein domains maintain their structure and function independently of the proteins in which they are found. e.g. an SH3 domain.
message ProteinDomain
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  gene hasGeneOrGeneProduct = 0
 }
message ProteinFamily
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  gene hasGeneOrGeneProduct = 0
 }
// Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/
message ProteinIsoform
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// Any published piece of information. Can refer to a whole publication, its encompassing publication (i.e. journal or book) or to a part of a publication, if of significant knowledge scope (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web, as well as printed materials, either directly or in one of the Publication Biolink category subclasses.
message Publication
 {
  iriType iri = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 repeated  string authors = 0
 repeated  string pages = 0
  string summary = 0
 repeated  string keywords = 0
 repeated  uriorcurie meshTerms = 0
 repeated  uriorcurie xref = 0
  string id = 0
  labelType name = 0
  string type = 0
 }
// A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value
message QuantityValue
 {
  unit hasUnit = 0
  double hasNumericValue = 0
 }
message ReactionToCatalystAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  integer stoichiometry = 0
  reactionDirectionEnum reactionDirection = 0
  reactionSideEnum reactionSide = 0
  molecularEntity subject = 0
  geneOrGeneProduct object = 0
 }
message ReactionToParticipantAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  chemicalEntity object = 0
  integer stoichiometry = 0
  reactionDirectionEnum reactionDirection = 0
  reactionSideEnum reactionSide = 0
  molecularEntity subject = 0
 }
// A gene altered in its expression level in the context of some experiment as a result of being targeted by gene-knockdown reagent(s) such as a morpholino or RNAi.
message ReagentTargetedGene
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
  biologicalSequence hasBiologicalSequence = 0
 }
// An OWL property used as an edge label
message RelationshipType
 {
  string id = 0
 }
// A result of a relative frequency analysis.
message RelativeFrequencyAnalysisResult
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
message RNAProduct
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// Represents a protein that is a specific isoform of the canonical or reference RNA
message RNAProductIsoform
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// An association between a sequence feature and a nucleic acid entity it is localized to.
message SequenceAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
 }
// For example, a particular exon is part of a particular transcript or gene
message SequenceFeatureRelationship
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  nucleicAcidEntity subject = 0
  nucleicAcidEntity object = 0
 }
// An allele that varies in its sequence from what is considered the reference allele at that locus.
message SequenceVariant
 {
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  gene hasGene = 0
  biologicalSequence hasBiologicalSequence = 0
  string id = 0
 }
// This class may rarely be instantiated except if use cases of a given knowledge graph support its utility.
message Serial
 {
  iriType iri = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 repeated  string authors = 0
 repeated  string pages = 0
  string summary = 0
 repeated  string keywords = 0
 repeated  uriorcurie meshTerms = 0
 repeated  uriorcurie xref = 0
  labelType name = 0
  string isoAbbreviation = 0
  string volume = 0
  string issue = 0
  string id = 0
  string type = 0
 }
// describes the severity of a phenotypic feature or disease
message SeverityValue
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules.
message SiRNA
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 repeated  labelType synonym = 0
 }
// A small molecule entity is a molecular entity characterized by availability in small-molecule databases of SMILES, InChI, IUPAC, or other unambiguous representation of its precise chemical structure; for convenience of representation, any valid chemical representation is included, even if it is not strictly molecular (e.g., sodium ion).
message SmallMolecule
 {
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  string id = 0
 }
// SNVs are single nucleotide positions in genomic DNA at which different sequence alternatives exist
message Snv
 {
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  gene hasGene = 0
  biologicalSequence hasBiologicalSequence = 0
  string id = 0
 }
// Attributes relating to a socioeconomic manifestation
message SocioeconomicAttribute
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }
// A socioeconomic exposure is a factor relating to social and financial status of an affected individual (e.g. poverty).
message SocioeconomicExposure
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 repeated  socioeconomicAttribute hasAttribute = 0
  timeType timepoint = 0
 }
// A group of people banded together or treated as a group as participants in a research study.
message StudyPopulation
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
message TaxonToTaxonAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  organismTaxon subject = 0
  organismTaxon object = 0
 }
// A descriptor for the rank within a taxonomic classification. Example instance: TAXRANK:0000017 (kingdom)
message TaxonomicRank
 {
  string id = 0
 }
// A result of text mining.
message TextMiningResult
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  string license = 0
  string rights = 0
  string format = 0
  date creationDate = 0
 }
// An RNA synthesized on a DNA or RNA template by an RNA polymerase.
message Transcript
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
  boolean isMetabolite = 0
  biologicalSequence hasBiologicalSequence = 0
 repeated  organismTaxon inTaxon = 0
 }
// A gene is a collection of transcripts
message TranscriptToGeneRelationship
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  transcript subject = 0
  gene object = 0
 }
// A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures', medical devices and/or procedures
message Treatment
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  drug hasDrug = 0
 repeated  device hasDevice = 0
 repeated  procedure hasProcedure = 0
  timeType timepoint = 0
 }
message VariantAsAModelOfDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  predicateType predicate = 0
  namedThing object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  sequenceVariant subject = 0
 }
message VariantToDiseaseAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  namedThing subject = 0
  predicateType predicate = 0
  namedThing object = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
 }
// An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)
message VariantToGeneAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  gene object = 0
  predicateType predicate = 0
 }
// An association between a variant and expression of a gene (i.e. e-QTL)
message VariantToGeneExpressionAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  namedThing subject = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  gene object = 0
  predicateType predicate = 0
  ontologyClass quantifierQualifier = 0
  anatomicalEntity expressionSite = 0
  lifeStage stageQualifier = 0
  diseaseOrPhenotypicFeature phenotypicState = 0
 }
message VariantToPhenotypicFeatureAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  namedThing object = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  sequenceVariant subject = 0
  frequencyValue frequencyQualifier = 0
  severityValue severityQualifier = 0
  onset onsetQualifier = 0
  biologicalSex sexQualifier = 0
 }
// An association between a variant and a population, where the variant has particular frequency in the population
message VariantToPopulationAssociation
 {
  string id = 0
  iriType iri = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
  predicateType predicate = 0
  boolean negated = 0
 repeated  ontologyClass qualifiers = 0
 repeated  publication publications = 0
 repeated  evidenceType hasEvidence = 0
  informationResource knowledgeSource = 0
  string originalKnowledgeSource = 0
  informationResource primaryKnowledgeSource = 0
 repeated  informationResource aggregatorKnowledgeSource = 0
  timeType timepoint = 0
  string type = 0
 repeated  categoryType category = 0
  sequenceVariant subject = 0
  populationOfIndividualOrganisms object = 0
  double hasQuotient = 0
  integer hasCount = 0
  integer hasTotal = 0
  double hasPercentage = 0
  frequencyValue frequencyQualifier = 0
 }
// A virus is a microorganism that replicates itself as a microRNA and infects the host cell.
message Virus
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
 repeated  organismTaxon inTaxon = 0
 repeated  attribute hasAttribute = 0
 }
message Vitamin
 {
  string id = 0
  iriType iri = 0
  string type = 0
  labelType name = 0
  narrativeText description = 0
  string source = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  chemicalEntity tradeName = 0
 repeated  drugAvailabilityEnum availableFrom = 0
  string maxToleratedDose = 0
  boolean isToxic = 0
 repeated  chemicalRole hasChemicalRole = 0
 }
message Zygosity
 {
  string id = 0
  string type = 0
  narrativeText description = 0
 repeated  attribute hasAttribute = 0
 repeated  string providedBy = 0
 repeated  uriorcurie xref = 0
 repeated  categoryType category = 0
  labelType name = 0
  ontologyClass hasAttributeType = 0
 repeated  quantityValue hasQuantitativeValue = 0
  namedThing hasQualitativeValue = 0
  iriType iri = 0
  string source = 0
 }