diff --git a/crates/timsrust-tdf/src/frame_reader.rs b/crates/timsrust-tdf/src/frame_reader.rs
index e3882a2..dc8aa77 100644
--- a/crates/timsrust-tdf/src/frame_reader.rs
+++ b/crates/timsrust-tdf/src/frame_reader.rs
@@ -2,7 +2,7 @@ pub(crate) mod compression1;
 pub(crate) mod compression2;
 pub(crate) mod frame_info_reader;
 
-use std::collections::HashMap;
+use std::collections::{HashMap, HashSet};
 
 use timsrust_core::{FrameIons, utils::reader::Reader};
 
@@ -31,13 +31,19 @@ use super::{
 struct TdfOffsetIonReader<B> {
     blob_reader: B,
     offsets: HashMap<usize, usize>,
+    empty_frames: HashSet<usize>,
 }
 
 impl<B> TdfOffsetIonReader<B> {
-    fn new(blob_reader: B, offsets: HashMap<usize, usize>) -> Self {
+    fn new(
+        blob_reader: B,
+        offsets: HashMap<usize, usize>,
+        empty_frames: HashSet<usize>,
+    ) -> Self {
         Self {
             blob_reader,
             offsets,
+            empty_frames,
         }
     }
 }
@@ -54,6 +60,9 @@ where
             .get(&index)
             .copied()
             .ok_or(FrameReaderError::IndexOutOfBounds)?;
+        if self.empty_frames.contains(&index) {
+            return Ok(FrameIons::default());
+        }
         self.blob_reader.get(offset).map_err(FrameReaderError::from)
     }
 }
@@ -113,19 +122,24 @@ impl TdfFrameReader {
     ) -> Result<Self, FrameReaderError> {
         let info_reader = FrameInfoReader::new(&path)?;
         let offsets = info_reader.offsets_map();
+        let empty_frames = info_reader.empty_frames();
         let ion_reader = match compression_type {
             1 => {
                 let mut blob =
                     TdfBlobReaderCompression1::new(path.to_timstof_path())?;
                 blob.set_max_peaks_per_scan(max_peaks_per_scan);
                 TdfIonReader::Compression1(TdfOffsetIonReader::new(
-                    blob, offsets,
+                    blob,
+                    offsets,
+                    empty_frames,
                 ))
             },
             2 => {
                 let blob = TdfBlobReader::new(path.to_timstof_path())?;
                 TdfIonReader::Compression2(TdfOffsetIonReader::new(
-                    blob, offsets,
+                    blob,
+                    offsets,
+                    empty_frames,
                 ))
             },
             _ => {
@@ -186,3 +200,50 @@ pub enum FrameReaderError {
     #[error("{0}")]
     CoreFrameReaderError(#[from] timsrust_core::FrameReaderError),
 }
+
+#[cfg(test)]
+mod tests {
+    use std::{
+        cell::Cell,
+        collections::{HashMap, HashSet},
+    };
+
+    use timsrust_core::{FrameIons, utils::reader::Reader};
+
+    use super::{FrameReaderError, TdfOffsetIonReader};
+    use crate::frame_reader::compression2::TdfBlobReaderError;
+
+    struct FailingBlobReader(Cell<usize>);
+
+    impl Reader<FrameIons> for FailingBlobReader {
+        type Error = TdfBlobReaderError;
+
+        fn get(&self, _offset: usize) -> Result<FrameIons, Self::Error> {
+            self.0.set(self.0.get() + 1);
+            Err(TdfBlobReaderError::CorruptFrame)
+        }
+    }
+
+    #[test]
+    fn zero_peak_frame_skips_the_binary_reader_without_masking_other_errors() {
+        let reader = TdfOffsetIonReader::new(
+            FailingBlobReader(Cell::new(0)),
+            HashMap::from([(1, 0), (2, 8)]),
+            HashSet::from([1]),
+        );
+
+        assert_eq!(reader.get(1).unwrap(), FrameIons::default());
+        assert_eq!(reader.blob_reader.0.get(), 0);
+        assert!(matches!(
+            reader.get(2),
+            Err(FrameReaderError::TdfBlobReaderError(
+                TdfBlobReaderError::CorruptFrame
+            ))
+        ));
+        assert_eq!(reader.blob_reader.0.get(), 1);
+        assert!(matches!(
+            reader.get(3),
+            Err(FrameReaderError::IndexOutOfBounds)
+        ));
+    }
+}
diff --git a/crates/timsrust-tdf/src/frame_reader/frame_info_reader.rs b/crates/timsrust-tdf/src/frame_reader/frame_info_reader.rs
index e800e3c..fcf716c 100644
--- a/crates/timsrust-tdf/src/frame_reader/frame_info_reader.rs
+++ b/crates/timsrust-tdf/src/frame_reader/frame_info_reader.rs
@@ -1,4 +1,7 @@
-use std::{collections::HashMap, sync::Arc};
+use std::{
+    collections::{HashMap, HashSet},
+    sync::Arc,
+};
 
 use timsrust_core::{
     AcquisitionType, FrameInfo, MSLevel, QuadrupoleSettings,
@@ -17,6 +20,7 @@ use crate::{
 pub struct FrameInfoReader {
     frame_infos: HashMap<usize, FrameInfo>,
     offsets: HashMap<usize, usize>,
+    empty_frames: HashSet<usize>,
     acquisition: AcquisitionType,
 }
 
@@ -26,6 +30,11 @@ impl FrameInfoReader {
     ) -> Result<Self, FrameReaderErrorInternal> {
         let tdf_sql_reader = SqlReader::open(&path)?;
         let sql_frames = SqlFrame::from_sql_reader(&tdf_sql_reader)?;
+        let empty_frames = sql_frames
+            .iter()
+            .filter(|frame| frame.peak_count == 0)
+            .map(|frame| frame.id)
+            .collect();
         let acquisition = if sql_frames.iter().any(|x| x.msms_type == 8) {
             AcquisitionType::DDAPASEF
         } else if sql_frames.iter().any(|x| x.msms_type == 9) {
@@ -94,6 +103,7 @@ impl FrameInfoReader {
         let reader = Self {
             frame_infos,
             offsets,
+            empty_frames,
             acquisition,
         };
         Ok(reader)
@@ -149,6 +159,10 @@ impl FrameInfoReader {
     ) -> std::collections::HashMap<usize, usize> {
         self.offsets.clone()
     }
+
+    pub(crate) fn empty_frames(&self) -> HashSet<usize> {
+        self.empty_frames.clone()
+    }
 }
 
 impl IndexedReader<FrameInfo> for FrameInfoReader {